78 Comparison of pierced versus broken capsules on delivered fine particle dose for the colistimethate dry powder inhaler
نویسندگان
چکیده
منابع مشابه
Handling of inhaler devices in actual pulmonary practice: metered-dose inhaler versus dry powder inhalers.
BACKGROUND Handling of inhaler devices such as pressurized metered-dose inhalers (MDIs) and dry-powder inhalers (DPIs) in actual pulmonary practice is not well studied. OBJECTIVE The aim of this study was to evaluate patients' proper handling of inhaler devices during actual pulmonary practice. METHODS Prospective observational evaluations were conducted at 3 pulmonary clinics in Jordan, fr...
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Dry powder inhalers (DPIs) are distinguished from one another by their unique device geometries, reflecting their distinct drug detachment mechanisms, which can be broadly classified into either aerodynamic or mechanical-based detachment forces. Accordingly, powder particles experience different aerodynamic and mechanical forces depending on the inhaler. However, the influence of carrier partic...
متن کاملDry powder inhaler formulation.
A drug product combines pharmacologic activity with pharmaceutical properties. Desirable performance characteristics are physical and chemical stability, ease of processing, accurate and reproducible delivery to the target organ, and availability at the site of action. For the dry powder inhaler (DPI), these goals can be met with a suitable powder formulation, an efficient metering system, and ...
متن کاملDeposition and fine particle production during dynamic flow in a dry powder inhaler: a CFD approach.
In this work the dynamic flow as well as the particle motion and deposition in a commercial dry powder inhaler, DPI (i.e., Turbuhaler) is described using computational fluid dynamics, CFD. The dynamic flow model presented here is an extension of a steady flow model previously described in Milenkovic et al. (2013). The model integrates CFD simulations for dynamic flow, an Eulerian-fluid/Lagrangi...
متن کاملIn vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy
BACKGROUND Combining in vitro mouth-throat deposition measurements, cascade impactor data and computational fluid dynamics (CFD) simulations, four different inhalers were compared which are indicated for chronic obstructive pulmonary disease (COPD) treatment. METHODS The Respimat inhaler, the Breezhaler, the Genuair, and the Ellipta were coupled to the idealized Alberta throat model. The mode...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2014
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(14)60214-9